I've watched Scrubs from the start and have continued to do so after my move to Pakistan (thank you bittorrent). I think to really enjoy Scrubs you need to be able to catch all the cultural miscellanea they throw at you and have an appreciation for the entirely self deprecating style of humor that JD and Turk employ. I love it.
As far as HIMYM is concerned, it is probably my favorite show on TV right now. Neil Patrick Harris is what pulls this show together, he is just, say it with me, AWESOME! I find it particularly amusing that he is actually gay, yet he plays this chauvinistic, blow hard which you would definitely not associate with him, given his Doogie Howser background. I think his character is definitely inspired by his role in Harold and Kumar...
Other shows I love: Weeds, Boston Legal, Family Guy, Entourage, Crumbs and Grey's Anatomy (guilty pleasure).
I've heard a lot about Mad Men, so I want to get into that soon.